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Effect of ginger on hepatotoxicity and nephrotoxicity induced by malathion in rats |
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PP: 63-76 |
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doi:10.18576/jans/010203
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Author(s) |
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Mohamed S Abdelbaky,
Mohamed Sobhy Hamad,
Reem E El-Soauly,
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Abstract |
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| This study aimed to determine the degree to which different doses of ginger can mitigate the adverse effects of malathion. Thirty-five male Sprague-Dawley rats aged 12 weeks weighed between 200 and 220 grams each. Animals were divided into seven groups of equal size, each consisting of five rats. The length of the experiment was restricted to 28 days. Group one served as the control and was given only a standard diet; groups two and three were given malathion alone throughout the experiment (at two doses; 50 mg/kg/day and 200 mg/kg/day, respectively); group four was given 50 mg/kg/day malathion and 400 mg/kg/day ginger; group five was given 200 mg/kg/day malathion and 400 mg/kg/day ginger; group six was given 50 mg/kg/day malathion and 800 mg/kg/day ginger. The results showed that the levels of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine, uric acid, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides (TG), and total cholesterol (CHOL) were significantly increased in the malathion-treated groups (groups 2 and 3). However, groups 2 and 3 had significantly lower levels of body weight gain (BWG), food intake (FI), and food efficiency ratio (FER) than the control and ginger-treated groups. The histopathological studies revealed that, although some pathological features were observed in the malathion-treated groups, groups treated with different doses of ginger exhibited histopathological changes in liver and kidney tissues. In conclusion, varying doses of ginger could potentially lessen the hepatotoxicity and nephrotoxicity of malathion. |
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