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A finite Element Model for the Electrical Activity in Human Cardiac Tissues |
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PP: 25-33 |
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Author(s) |
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Shuaiby M. Shuaiby,
M. A. Hassan,
Abdel-Badie Sharkawy,
Abdel-Rasoul M.M.Gad,
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Abstract |
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| Biosimulation models of the heart action potential have become a very useful tool. It provides better understanding for the
complex biophysical phenomena related to electrical activity in the heart such as cardiac arrhythmias. At cellular level, the electrical
activity of cardiac tissues may be simulated by solving a system of ordinary deferential equations (ODEs) describing the electrical
behavior of the cell membrane. Because the biophysical processes underlying this phenomenon are non-linear and change very rapidly,
the ODE system is a challenge to be solved numerically. Furthermore, the implementation of these models is a hard task for commercial
finite element software. In this paper a finite element formulation, model and code generation of monodomain equation has been
conducted. The developed code is coupled with the modified FitzHugh-Nagumo (FHN) cell electrophysiological model in order to
have isotropic excitation propagation starting from cell level to complete heart level. MTALAB programming language was used to
build the proposed standalone finite element code. A two dimensional specimen of heart tissues is simulated to show the behavior of
the excitation propagation and the repolarization phase for isotropic electrical activity. Simulation results of the cardiac action potential
have shown good agreements with the experimental measurements obtained from published literature. |
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