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Theoretical Production of Copper-64 and Copper-67 and its Application in Radiotherapy |
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PP: 131-140 |
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doi:10.18576/jrna/100206
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Author(s) |
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George Edusei,
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Abstract |
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| The Talys-1.6 code, a nuclear reaction model, was employed to generate cross-sectional data for potential reaction paths leading to the production of copper-64 and copper-67 in a theoretical analysis. The optimal nuclear processes identified for producing 64Cu/67Cu involved the reactions 64Ni (p, n)64Cu and 70Zn (p, α) 67Cu. Analysis of the cross-section data for the 64Ni (p, n) 64Cu reaction indicated that copper-64 production is most effective within a proton energy range of 7MeV to 12MeV. Similarly, the cross-section data for the 70Zn (p, α) 67Cu reaction suggested that copper-67 generation is most efficient with proton energies ranging from 13MeV to 18MeV. The findings suggest that the production of 64Cu/67Cu is feasible in Ghana, provided low-energy cyclotrons (7MeV to 18MeV) are available, and production can be achieved with variable beam currents ranging from 50 to 200A. Comparison of different cross-sectional data with existing theoretical and experimental works in the literature showed favorable agreement. The thick target yield, determined using Simpsons numerical integration method and the radionuclide production yield equation by Qaim, resulted in thick target yields of 376MBq/A and 6.3MBq/A for the nuclear reactions 64Ni (p, n)64Cu and 70Zn (p, α) 67Cu, respectively. Additionally, this work reviews recent successful applications of copper-based radiopharmaceuticals in radiotherapy, SPECT imaging, and PET. The paper also presents intriguing findings in radioimmunotherapy, immunotherapy, and PET visualization of antibody biodistribution. |
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