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Is There A Role of Helicobacter Pylori Infection in Incidence of Acute Coronary Syndrome? |
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PP: 1-4 |
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doi:10.18576/ab/030101
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Author(s) |
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Ramadan Ghaleb,
Hossam Mansour,
Mohamed Omar Amer,
Ali Ismael,
Akshaya Srikanth Bhagavathula,
Abd Elrazek Abd Elrazek,
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Abstract |
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| Background: There is a growing interest in the bacterium’s association in extragastric diseases such as cardiovascular, neurological, hematological and uro-gynecological diseases. Aim: We aimed to investigate the correlation between acute coronary syndrome (ACS) and chronic infection of Helicobacter pylori (H.pylori) in Egyptian population. Methods: We prospectively evaluated 119 patients (from December 2016- February 2017) presented with typical chest pain and/or percutaneous coronary intervention revealed ACS are investigated to H.Pylori infection by antibodies (Ab) test of both acute and chronic infection. IgM and IgG tests respectively to evaluate the association between ACS and H.pylori infection. Univariable and multivariable Cox proportion hazards regression with a 95% confidence interval (CI) was used to measure the crude hazard ratio (HR) and adjusted HR (aHR) of ACS for the H.pylori infection. Results: The mean age of the study population was 57.9 ±11.2 [standard deviation (SD)] and having comorbidities like diabetes (46.2%), and hypertension (42%). ACS was confirmed in 94% of the whole study sample with H.pylori IgG antibodies (mean±SD: 2.36± 1.42 U/mL). The risk of developing ACS was significantly associated and increased with increasing age. The risk of developing ACS in patients with higher H.pylori IgG was 1.6 times (95% CI: 0.662-1.704). We also estimated the risk of ACS in relation to family history, the risk of developing ACS was nearly two-fold higher in patients with existence of family history of CVDs. Conclusion: However there are many presented with ACS, current risk factors cannot explain their ACS, hence chronic H. Pylori infection may play a role, need further researches evaluate the real condition |
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