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Synthesis, Characterization of Novel Furan Based Polymeric Nanoparticles and Their Biological Activitie |
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PP: 99-105 |
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doi:10.18576/ijnc/020305
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Author(s) |
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Dakshayini Chandrashekarachar,
M. Chaitramallu,
N. D. Rekha,
Devaraju Kesagudu,
P. Ranjini,
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Abstract |
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| PEGylation( polymeric substance) is clinically proven and attract both scientific and commercial interests, here we emphasize the overcome the drawback of solution phase methods, the five membered ring, imidazolone moiety is present in a wide range of naturally occurring molecules, for example furan is a five membered heterocyclic nucleus which contain oxygen atom as heteroatom having a broad spectrum of biological activity and here we attempt PEGlated product, involved free carbonyl terminal was used for conjugation via condensation. The solid matrix characterized by spectral studies and biological activity.we prepared a series of PEGylated 3-(4-Acetyl-phenyl)-5-aryldine-2-furan-2-yl-3,5dihydro- imidazol-4-one with different aldehydes through Erlenmeyer reaction and condensation methods by using PEGaldehyde .These newly synthesized compounds were characterized by IR, 1HNMR,MASS,SEM,DLS studies. All final compounds are screened for their antioxidant, anti- inflammatory activities done through by DPPH, Nitric oxide radical scavenging, ferrous ion chelating,Haemolytic assay and CAM assay. |
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