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Journal of Pharmaceutical and Applied Chemistry
An International Journal


Volumes > Vol. 4 > No. 2


In Vitro Antiproliferative and Antimicrobial Activity of 11-Epiartapshin Compound Isolated from SeriphidiumHerba-alba

PP: 147-154
M.Taher M. El-Wassimy, Mehawed M. Ahmed, Sabry H. H. Younes, Mohamed-Elamir F. Hegazy,
Seriphidium herba-alba (Asteraceae family) was known for its therapeutic and medicinal properties, it was used in both traditional and modern medicine. 11-Epiartapshin was isolated from S. herba-alba. The structure of the compound was elucidated by means of spectroscopic data analysis, including 1D/2D NMR techniques and compared with reported data from the literature. The isolated compound was subjected to antiproliferative potential activity against cancer cell lines of the liver (HepG-2), colon (HCT-116) and breast (MCF-7) using 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction Assay. As well as, the total extract of S. herba-alba and the purified 11-epiartapshin were tested for antimicrobial activity. 11-Epiartapshin showed moderate antibacterial effects against Gram-positive, Gram-negative bacteria and weak antifungal effect. Seriphidiumherba-alba total extract has good inhibitory activity against all tested pathogenic bacteria.

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