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Journal of Pharmaceutical and Applied Chemistry
An International Journal


Volumes > Vol. 2 > No. 2


Some Physical Parameters of PEG-modified Magnetite Nanofluids

PP: 33-37
J. Markhulia, V. Mikelashvili, Sh. Kekutia, L. Saneblidze, Z. Jabua, D. Daraselia, D.Jafaridze,
The development of the synthesis of stable aqueous suspensions of superparamagnetic iron oxide nanoparticles stabilized with unmodified polyethylene glycol (PEG) at two molecular weights (4000 and 6000 Da) and several PEG/iron ratios has been reported. The obtained biocompatible polymer (PEG) coated nanoparticle dispersive solution with pH ≈ 6.5 and solid phase content ranging from 0.02-0.75 % w/v has been investigated for optical and magnetic properties. Biomedical application requires the biocompatible superparamagnetic iron oxide nanoparticles (SPION), which are stable and well dispersed in water at physiological pH or in physiological salinity. Biocompatible 10-20 nm sized SPIONs have been synthesized via co-precipitation method in the vacuum environment. These SPIONs have been modified with PEG in one-pot synthesis. Vibrating Sample Magnetometer (VSM) studies show the effect of phase transformations on the magnetic properties of the nanoparticles and surfactant influence on the characteristic of the magnetization at room temperatures into high and low magnetic fields.

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